Description

1mg

1 vial

What is IGF-1 LR3 ?

IGF-1 LR3 is a synthetic peptide designed to resemble human insulin-like growth factor 1 with improved bioavailability. It is a longer peptide (LR3) that incorporates a substitution of glutamic acid with arginine at the third position. Additionally, an extra 13 amino acids are added to the N-terminal, resulting in a total of 83 amino acids, whereas regular IGF-1 consists of 70 amino acids. These modifications contribute to an extended half-life of IGF-1 LR3, ranging from 20 to 30 hours, compared to 12 to 15 hours for IGF-1. Furthermore, IGF-1 LR3 exhibits three times the potency of IGF-1 by reducing the binding of insulin-like growth factor binding proteins, thereby enhancing its overall biological activity.

IGF-1, similar to insulin, binds to its receptor IGFR1, stimulating cell growth, as well as muscle fiber growth and differentiation. IGF-1 LR3 serves as an efficient alternative to IGF-1 in both in vitro and in vivo studies due to its functional mimicry and effective receptor binding. For instance, research conducted on fetal myocyte proliferation and heart mass in a sheep model demonstrated that IGF-1 LR3 promotes cardiomyocyte proliferation and increases blood flow to the heart. In another study, C2C12 cells were treated in vitro and mice in a tumor model were treated in vivo with IGF-1 LR3, revealing its role in preventing muscle wasting in cancer. By activating the PI3K/AKT pathway and inhibiting the upregulation of muscle wasting factors, IGF-1 LR3 promotes protein synthesis.

IGF-1 LR3 is available as a lyophilized white powder in vials with a concentration of 1 mg/vial.

IGF-1 LR3 Info Based off of Research

Muscle Growth: IGF-1 LR3 is known for its potential to stimulate muscle growth and hypertrophy. It may support the development of lean muscle mass and increased muscle size.
Fat Loss: IGF-1 LR3 may promote the breakdown of stored fat (lipolysis), potentially aiding in weight loss and improved body composition.
Enhanced Recovery: Athletes and individuals engaged in strenuous physical activities may use IGF-1 LR3 to aid in muscle recovery, reduce soreness, and improve overall recovery times.
Anti-Aging Effects: IGF-1 is associated with anti-aging properties, including improved skin quality, reduced wrinkles, and increased vitality.
Improved Bone Density: Some studies suggest that IGF-1 may have the potential to improve bone density, which can be beneficial for bone health and reducing the risk of osteoporosis.
Joint Health: IGF-1 LR3 may support joint health and alleviate joint pain associated with conditions like osteoarthritis.
Enhanced Cognitive Function: While not its primary use, IGF-1 has been explored for its potential to improve cognitive function and memory in some studies.
Tissue Repair: IGF-1 is involved in tissue repair processes, and IGF-1 LR3 may accelerate wound healing and tissue regeneration.
Immune System Support: IGF-1 may support immune system function, potentially enhancing the body’s ability to fight off infections.
Neuroprotection: Some studies suggest that IGF-1 may have neuroprotective effects, which could be relevant for neurological conditions.