BPC-157

Alright, so you’ve heard the developing hype about BPC-157, and you’ve got questions. What the heck is it? How does it do what it’s claimed to do? How well does it actually work? Is it the big new thing in recovery medicine that it’s purported to be?

Wildly enough… It seems like the data may support these claims. From studies on dietary BPC-157 dosages effect on post stroke arterial and hippocampus tissue recovery rates, to musculoskeletal trauma treatment, this pentadecapeptide seems to be activating broad spectrum repair pathways in test subjects, and may even have promise in treating some mental disorders that are neuron damage related. So what does this mean to you?

Well, this compound lives in a grey area right now. The FDA hasn’t made a ruling on it, and it is neither widely endorsed nor discouraged by the medical community, though off label usage in doctors office is skyrocketing due to it’s ability to help with post surgical recovery and cardiovascular trauma treatment. Anyone looking to take advantage of this compound and use it for personal use would be doing so on their own recognizance and would be placing faith in their supplier to give them the real thing, and everyone should do their due diligence in sourcing peptides and research compounds. 

Does BPC-157 Live Up to the Hype?

In peer reviewed research as well as voluntary peptide pioneer usage, this compound has been observed to:

-Help treat brain damage resulting from strokes and emboli
-Aggressively improve healing and regeneration of damaged tissue (like something out of a sci-fi show to be honest)
-Decrease inflammation and inflammatory markers both in both vascular AND avascular structures, like cartilage and connective tissue
-Accelerate recovery time between training bouts
-Acts as a potent neuroprotective agent
-Drastically aids in post surgical recovery, increasing healing time and thus decreasing risk of infection or emboli formation, which is a really big deal for the surgical field.

 

    BPC-157 Dosing For Your Research Experiments

    For those of you who like the sound of this, and have a desire to test some of these claims, you’d just need a simple math equation to figure out how you would want to dose it for your own research.

    Injectables

    Where injectable peptides are concerned, the typical injection dose is between 200μg-800μg (that’s micrograms), and the dose would depend on what is being treated. Something like a bad cut or a surgical incision would call for a larger dose like 600μg-800μg, injected near the wound site, while something like a bruised joint or connective tissue injury like a rolled ankle would be a candidate for lower doses at longer usage durations. So where injections are concerned, consider the injury/symptom you’re treating for when deciding what dose to choose for your research.

    Oral

    For oral doses of BPC-157, research seems to suggest that the optimal dose should lie somewhere between 1.6μg/Kg of subject weight, or 0.73μg/Lb of bodyweight for those here in the US. For this equation, you would take the bodyweight of the test subject, multiply it by its given ratio of micrograms to pounds or kilograms, and then that will give you your daily oral research dose. It can be administered all at once or in multiple spread out doses, but some of the research seems to point to a higher efficacy in spreading out the doses, for both oral and injection routes. To make it easier to comprehend visually, here is a chart with the equations with given body weights for human subjects in imperial and metric

    Metric 1.6μg x Bodyweight in Kg = Dose in μg

    1.6μg x 60 Kg

    96 μg

    1.6μg x 70 Kg

    112 μg

    1.6μg x 80 Kg

    128 μg

    1.6μg x 90 Kg

    144 μg

    1.6μg x 100 Kg

    160 μg

    Imperial 0.73μg/ Bodyweight in Lb = Dose in μg

    0.73μg x 160 Lb

    116.8 μg

    0.73μg x 170 Lb

    124.1 μg

    0.73μg x 180 Lb

    131.4 μg

    0.73μg x 190 Lb

    138.7 μg

    0.73μg x 200 Lb

    146 μg

     

    Topicals

    The last usage method floating around out there are the creams/lotions. These are going to be an interesting research method to track. There are only a few peptides out there that happen to have structures that lend themselves to absorption in the capillary beds in our skin, and this just happens to be one of those times. BPC-157 and another compound called TB500 have both seen a large increase in usage as transdermal application candidates, and it makes them really easy to work with. They’re sold in their appropriate concentrations, ready to apply and have ingredients like DMSO to improve the absorption of the peptides more effectively. These salves, creams and lotions would be something one would just rub in around the general area of an injury multiple times a day, but would work about half as fast as injection administration. However, that is still a pretty stellar achievement considering there are no needles or calculations required. 

    More Information About BPC-157

    For those who want a little more information on it and like the fine details, BPC-157 is a pentadecapeptide that seems to activate pathways and systems throughout the body to trigger widespread anti-inflammatory, regenerative, homeostatic and autophagy related activity. The compound is observed to show up in freshly damaged tissues, and it is believe that it might either be the messenger or the trigger for the body to kick off the repair processes in the area around where it was detected in the body. There is still a lot that is unknown about the human genome and exactly how this compound performs the amazing feats that it does, but it seems to center around activating these systems, and testing of this peptide has been centered around finding out just how far the body will go to fix things when this peptide is introduced. 

    One of the craziest papers I’ve read yet seems to indicate that BPC-157 had been successfully used to improve multiple brain functions in rats that had complete arterial clampings performed to induce brain damage in multiple systems, which is something that could change a lot for those recovering from strokes. However it really illuminates that the proposed relationship that this peptide has with the nervous system both on the CNS spectrum and also the gut-brain/brain-gut axis may be more than just mere speculation. If that’s the case, there may even be a future for this peptide as a daily supplement for treatment for a wide variety of wear and tear related conditions in multiple systems of the body, and that’s something to get excited about. 

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