For laboratory research use only. Not for human consumption. All compounds referenced in this article are sold by Explicit SARMs solely as reference materials for in-vitro and animal research by qualified professionals. Nothing here is medical advice, and no statement has been evaluated by the FDA. These materials are not intended to diagnose, treat, cure or prevent any disease.
MK-677 attracts a lot of questions, and a lot of the answers online are wrong, starting with what kind of compound it is. Below are concise answers to the questions researchers ask us most often. Explicit SARMs supplies MK-677 capsules and MK-677 liquid strictly as laboratory reference material.
About the Compound
What is MK-677?
MK-677 (ibutamoren, MK-0677) is a non-peptide, small-molecule growth hormone secretagogue. It was developed as a ghrelin receptor (GHS-R1a) agonist, and research has examined its effects on growth hormone and IGF-1 signaling.
Is MK-677 a SARM?
No. SARMs act on androgen receptors, and MK-677 does not. It is often listed alongside SARMs by retailers, but its mechanism is entirely different.
Is MK-677 a peptide?
No. It mimics the action of the peptide hormone ghrelin, but MK-677 itself is a small organic molecule, not a chain of amino acids.
Is MK-677 approved for any use?
No. It is not approved by the FDA for any indication, and it is on the World Anti-Doping Agency’s prohibited list.
What the Research Covers
What has been studied?
Published work has looked mainly at its effect on growth hormone pulsatility and IGF-1 levels, along with related endpoints such as body composition, sleep architecture and appetite signaling. Our MK-677 research overview summarizes this literature, and the half-life article covers what the pharmacokinetic studies report.
Where does the evidence stop?
Findings from specific study populations and designs should not be generalized beyond them. Long-term data are limited, and changes in a hormone level are not the same thing as a functional outcome.
Our Products
What formulations are available?
We offer capsules and a liquid. The capsules vs liquid comparison explains how the two differ for protocol design.
How is it tested?
Our products come from US domestic manufacturing with two tests by our manufacturer, plus purity testing by an independent third-party lab. A COA is available on request through our contact page.
Can you advise on dosing or use?
No. MK-677 is sold strictly for laboratory research, and we do not provide dosing, administration or usage guidance.