MELANOTAN II 10mg (MT2)

10mg

1 vial

Molecular Formula: C₅₀H₆₉N₁₅O₉

What is Melanotan II?

MELANOTAN II 10mg is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH). Acting as an agonist at the melanocortin-3 and 4 receptors (MC3R and MC4R), Melanotan II shares similarities with the prohormone pro-opiomelanocortin (POMC) cleavage peptides, including adrenocorticotropin hormone (ACTH) and α-, β-, and γ-MSH. The melanocortin system, encompassing the central nervous system, plays a role in regulating various physiological functions such as cardiovascular function, energy balance, hunger, glucose and lipid homeostasis, sexual function, pituitary gland functions, emotional behavior, cachexia, drug abuse behavior, pain perception, and anxiety behavior.

In a laboratory study utilizing an MC4R knockout model in rats, increased food intake, body weight gain, and fat accumulation were observed. Additionally, brain administration of melanotan II did not alter feeding behavior, confirming the loss of MC4R function. Subcutaneous treatment with melanotan II in neonate prairie voles resulted in reduced play-fighting in male voles during adulthood and enhanced partner preference in female voles during adulthood.

It has been noted that melanocortin signaling is essential for the antidiabetic effects of leptin. In an experiment, the glucose-lowering effect of leptin was countered by pretreatment with MC3R or MC4R antagonist via intra-cerebroventricular (ICV) administration, highlighting the significance of normal melanocortin signaling in mediating the effects of leptin. However, ICV infusion of MC3R or MC4R agonists alone does not effectively control hyperglycemia in diabetic rats, indicating that increased melanocortin activity alone cannot fully account for the glucose-lowering effect of leptin. Given its wide range of effects, including body weight, metabolism, and thermoregulation, melanotan II serves as a valuable reagent in in vitro laboratory settings for conducting diverse experiments.

Melanotan II is provided as a lyophilized white powder in a vial with a concentration of 10 mg/vial.

Melanotan Info Based off of Research

1. Increased Skin Pigmentation: Melanotan is primarily used for its ability to stimulate the production of melanin, the pigment responsible for skin color. This can result in increased skin pigmentation, leading to a tan or darker complexion.
2. UV Protection: Melanin acts as a natural protector against the harmful effects of ultraviolet (UV) radiation from the sun. A darker skin tone can provide some degree of protection against sunburn and UV-induced skin damage.
3. Reduced Sunburn Risk: Individuals with increased skin pigmentation may have a reduced risk of sunburn when exposed to UV radiation. This can be particularly beneficial for people who are sensitive to the sun.
4. Enhanced Cosmetic Appearance: Some individuals use Melanotan to achieve a tan or darker skin tone for cosmetic reasons, as it can be perceived as more attractive by some.
5. Appetite Suppression: Some users have reported appetite suppression as a side effect of Melanotan II. This effect can be used by individuals looking to control their calorie intake and manage weight.
6. Improved Sexual Function: Some anecdotal reports suggest that Melanotan II may increase sexual desire and arousal in both men and women. However, further research is needed to confirm this effect.

Studies/Resources

• Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide: tanning activity and spontaneous erections in humans
• Melanotan II User Experience: Qualitative Study of Online Forums (UK/Ireland, 2016–2017)

Safety Disclaimer

This product is intended for research purposes only. It is not intended for human consumption or medical use.