MOTS-c and SS-31 both come up in mitochondrial research, but they are very different molecules. MOTS-c is a peptide encoded by mitochondrial DNA. SS-31 is a small synthetic peptide designed to reach the inner mitochondrial membrane.
Side-by-side
| MOTS-c | SS-31 | |
|---|---|---|
| Type | Mitochondrial-derived peptide | Synthetic Szeto-Schiller tetrapeptide |
| Length | 16 amino acids | 4 amino acids |
| Other name | — | Elamipretide |
| CAS number | 1627580-64-6 | 736992-21-5 |
| Molecular formula | C101H152N28O22S2 | C32H49N9O5 |
| Molecular weight | 2174.6 g/mol | 639.8 g/mol |
MOTS-c
MOTS-c was described in 2015 by Lee and colleagues in Cell Metabolism. It is encoded by a short open reading frame in the mitochondrial 12S rRNA gene. Laboratory studies have focused on its role in metabolic signaling, including the AMPK pathway, in cell and rodent models.
SS-31
SS-31 was developed by Hazel Szeto and Peter Schiller. Its sequence is D-Arg-Dmt-Lys-Phe-NH2, and research has centered on how it binds cardiolipin, a lipid in the inner mitochondrial membrane.
Formats and prices
| Product | Format | Price |
|---|---|---|
| MOTS-C 5mg | Lyophilized powder, 5mg per vial | $75.00 |
| MOTS-C 10mg | Lyophilized powder, 10mg per vial | $95.00 |
| MOTS-C 40mg | Lyophilized powder, 40mg per vial | $195.00 |
| SS-31 50mg | 50mg per vial | $155.00 |
Prices as of November 2026.
Testing
Our manufacturer tests it twice during production, and we use an independent third-party lab for purity testing. A COA is available on request.
FAQ
What is the difference between MOTS-c and SS-31?
MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA. SS-31 (elamipretide) is a synthetic four-amino-acid peptide that binds cardiolipin in the inner mitochondrial membrane.
When was MOTS-c discovered?
MOTS-c was described in 2015 by Lee and colleagues in Cell Metabolism.
What are the CAS numbers for MOTS-c and SS-31?
MOTS-c is CAS 1627580-64-6 and SS-31 is CAS 736992-21-5.
What sizes does Explicit SARMs carry?
MOTS-c comes in 5mg, 10mg and 40mg vials, and SS-31 in a 50mg vial, all for laboratory research use only.
Are MOTS-c and SS-31 tested?
Our manufacturer tests it twice during production, and we use an independent third-party lab for purity testing. A COA is available on request.
All products mentioned are sold for laboratory research use only and are not for human consumption.