Tesamorelin and Sermorelin are both synthetic analogs of growth hormone-releasing hormone (GHRH). They differ in length and in one chemical modification, and labs study them as tools for GHRH receptor research.
Side-by-side
| Tesamorelin | Sermorelin | |
|---|---|---|
| Based on | Full-length GHRH(1-44) | GHRH(1-29) fragment |
| Length | 44 amino acids | 29 amino acids |
| Modification | trans-3-hexenoyl group on the N-terminus | C-terminal amide |
| CAS number | 218949-48-5 | 86168-78-7 |
| Molecular formula | C221H366N72O67S | C149H246N44O42S |
| Molecular weight | about 5135.9 g/mol | about 3357.9 g/mol |
Tesamorelin
Tesamorelin keeps all 44 amino acids of human GHRH and adds a trans-3-hexenoyl group to the first residue. That change was designed to make the peptide more resistant to breakdown by the enzyme DPP-4 in laboratory studies.
Sermorelin
Sermorelin is the first 29 amino acids of GHRH, the shortest fragment that keeps full activity at the GHRH receptor in published binding studies. It was one of the first GHRH analogs studied.
Formats and prices
| Product | Format | Price |
|---|---|---|
| Tesamorelin 2mg | Lyophilized powder, 2mg per vial | $50.00 |
| Tesamorelin 5mg | Lyophilized powder, 5mg per vial | $75.00 |
| Tesamorelin 10mg | Lyophilized powder, 10mg per vial | $95.00 |
| Tesamorelin 20mg | Lyophilized powder, 20mg per vial | $135.00 |
| Tesamorelin/Ipamorelin 10mg | Blend vial, 5mg + 5mg | $90.00 |
| Sermorelin 5mg | Lyophilized powder, 5mg per vial | $44.99 |
| Sermorelin 10mg | Lyophilized powder, 10mg per vial | $95.00 |
Prices as of November 2026.
Testing
Our manufacturer tests it twice during production, and we use an independent third-party lab for purity testing. A COA is available on request.
FAQ
What is the difference between Tesamorelin and Sermorelin?
Tesamorelin is the full 44-amino-acid GHRH sequence with a trans-3-hexenoyl group added. Sermorelin is the 29-amino-acid GHRH(1-29) fragment.
What are the CAS numbers?
Tesamorelin is CAS 218949-48-5 and Sermorelin is CAS 86168-78-7.
What sizes does Explicit SARMs carry?
Tesamorelin comes in 2mg, 5mg, 10mg and 20mg vials plus a Tesamorelin/Ipamorelin blend. Sermorelin comes in 5mg and 10mg vials.
Who are they sold for?
Both are sold for laboratory research use only.
Are they tested?
Our manufacturer tests it twice during production, and we use an independent third-party lab for purity testing. A COA is available on request.
All products mentioned are sold for laboratory research use only and are not for human consumption.