GHRP-6 -5mg

5mg

1 vial

Molecular Formula: C₄₆H₅₅N₁₂O₆

What is GHRP-6?

GHRP-6, also known as growth hormone-releasing peptide 6 or growth hormone-releasing hexapeptide, is a synthetic mimetic of ghrelin. Initially discovered as a growth hormone secretagogue receptor (GHS-R) binder, researchers later identified ghrelin as the endogenous ligand for GHS-R. Consequently, GHRP-6 is considered a mimetic of ghrelin. Ghrelin, consisting of 28 amino acids, is involved in hunger signaling, regulating food intake, and stimulating growth hormone (GH) release.

GHRP-6 differs from growth hormone-releasing hormone (GHRH) in amino acid sequence and receptor binding. However, when administered together, GHRP-6 and GHRH exhibit synergistic effects, enhancing GH release. This is attributed to GHRP-6’s impact on both the pituitary gland and hypothalamus.

Comprising only 6 amino acids, including unnatural D-amino acids, GHRP-6 has a molecular weight of 929.48 g/mol. The sequence is as follows: L-Histidine, D-Tryptophan, L-Alanine, L-Tryptophan, D-Phenylalanine, and L-Lysine. The inclusion of D-amino acids in the synthetic peptide allows it to stimulate GH secretion from the anterior pituitary gland while inhibiting the function of somatostatin, a hormone that blocks GH release. GH, in turn, stimulates insulin-like growth factors (IGFs), which play crucial roles in metabolism, cell proliferation, and protein synthesis.

Studies in fish have shown that supplementing feed with GHRP-6 at doses of 100 µg/kg or 500 µg/kg improves growth performance. The lower dose enhances aerobic metabolism, while the higher dose increases GH levels comparable to ghrelin. Furthermore, GHRP-6 has demonstrated neuroprotective effects in ischemic stroke cases. In a gerbil model of stroke, combining GHRP-6 with recombinant epidermal growth factor (rhEGF) improved neurological outcomes and survival.

GHRP-6 is available as a white lyophilized powder in 5 mg/vial concentration. It is intended solely for laboratory research purposes.

GHRP-6 Info Based off of Research

1. Stimulation of Growth Hormone Release: GHRP-6 is known for its ability to stimulate the release of growth hormone (GH) from the pituitary gland. Increased GH levels can have several potential benefits.
2. Muscle Growth: Higher GH levels can support muscle growth and development, making it of interest to athletes and bodybuilders.
3. Fat Loss: GHRP-6 may promote the breakdown of stored fat (lipolysis), potentially aiding in weight loss and improving body composition.
4. Improved Appetite: Some users of GHRP-6 have reported an increase in appetite, which may be beneficial for individuals looking to increase calorie intake.
5. Enhanced Recovery: Athletes and individuals engaged in strenuous physical activities may use GHRP-6 to aid in muscle recovery, reduce soreness, and improve overall recovery times.
6. Anti-Aging Effects: GH is associated with anti-aging properties, including improved skin quality, reduced wrinkles, and increased vitality.
7. Improved Bone Density: GHRP-6 may have the potential to improve bone density, which can be beneficial for bone health and reducing the risk of osteoporosis.
8. Enhanced Mood and Cognitive Function: Some users have reported improved mood, mental clarity, and cognitive function with the use of GHRP-6.
9. Immune System Support: Increased GH levels can support immune system function, potentially enhancing the body’s ability to fight off infections.
10. Libido and Sexual Function: Improved GH levels may positively influence libido and sexual function in both men and women.
11. Cardiovascular Health: Some studies suggest that GH may have cardiovascular benefits, such as improved cholesterol profiles and reduced risk factors for heart disease.
12. Wound Healing: GHRP-6 has been explored for its potential to enhance wound healing, including chronic wounds that are slow to heal.

Studies/Resources

• Pharmacokinetics of intravenous GHRP‑6 in healthy volunteers (100–400 µg/kg)
• GHRP‑6 provides cardio- and cytoprotection, extending beyond GH release (Frontiers in Pharmacology, 2024)

Safety Disclaimer

This product is intended for research purposes only. It is not intended for human consumption or medical use.