For laboratory research use only. Not for human consumption. Sold by Explicit SARMs solely as reference material for in-vitro and animal research by qualified professionals. Not evaluated by the FDA and not intended to diagnose, treat, cure or prevent any disease.
By Explicit SARMs Team
RAD-140 (testolone) and LGD-4033 (ligandrol) are both nonsteroidal selective androgen receptor modulators (SARMs). Researchers compare them because they share a target, the androgen receptor, but differ in structure, origin and the published literature behind each one. This page sets out what the published research and the compounds’ reference data show, for laboratory research only.
Side-by-side comparison
| RAD-140 (testolone) | LGD-4033 (ligandrol) | |
|---|---|---|
| Class | Nonsteroidal SARM (androgen receptor ligand) | Nonsteroidal SARM (androgen receptor ligand) |
| CAS | 1182367-47-0 | 1165910-22-4 |
| Formula / MW | C20H16ClN5O2 / 393.8 | C14H12F6N2O / 338.3 |
| Developer | Radius Health | Ligand Pharmaceuticals |
| Key published paper | Preclinical characterization, Miller et al. 2011 (PMID 24900290) | Clinical pharmacokinetics study, Basaria et al. 2013 (PMID 22459616) |
| WADA | Named in section S1 | Named in section S1 |
| Explicit SARMs formats | 90 capsules, 10mg each; liquid, 30ml at 30mg/ml | 90 capsules, 10mg each; liquid |
What the literature covers
RAD-140 was designed and characterized preclinically by Radius Health, with tissue-selectivity data from rodent and primate models reported in its 2011 design paper (Miller et al.). LGD-4033 has a published clinical pharmacokinetics study (Basaria et al., 2013). Both are reviewed alongside other SARMs in Narayanan et al. (2018).
Structural differences
The two molecules come from different chemical series. RAD-140 contains a chlorinated benzonitrile core with an oxadiazole group, while LGD-4033 is a pyrrolidinyl-benzonitrile carrying two trifluoromethyl groups. These differences matter for researchers choosing a reference standard for receptor-binding or analytical work.
How Explicit SARMs tests these compounds
Our manufacturer tests it twice during production, and we use an independent third-party lab for purity testing. A COA is available on request.
Related research compounds
- RAD-140 Testolone capsules
- LGD-4033 Ligandrol capsules
- Ostarine MK-2866 capsules
- Ostarine (MK-2866) vs RAD-140
FAQ
What is the main difference between RAD-140 and LGD-4033?
Both are nonsteroidal androgen receptor ligands, but they have different chemical structures, CAS numbers and developers, and a different body of published research: RAD-140 is mainly characterized preclinically, while LGD-4033 has a published clinical pharmacokinetics study.
Are RAD-140 and LGD-4033 on the WADA prohibited list?
Yes. Both are named in section S1 of the WADA Prohibited List.
What formats does Explicit SARMs supply?
Both are available as 90-capsule bottles at 10mg per capsule and as liquids, for laboratory research use only.
How are they tested?
Our manufacturer tests it twice during production, and we use an independent third-party lab for purity testing. A COA is available on request.
Published research cited
- Miller CP, et al. Design, synthesis, and preclinical characterization of the selective androgen receptor modulator (SARM) RAD140. ACS Med Chem Lett. 2011;2(2):124-129. PMID 24900290.
- Basaria S, et al. LGD-4033 clinical pharmacokinetics study. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. PMID 22459616.
- Narayanan R, Coss CC, Dalton JT. Development of selective androgen receptor modulators (SARMs). Mol Cell Endocrinol. 2018;465:134-142. PMID 28624515.